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Studio dei meccanismi biologici responsabili della trasformazione tumorale e della risposta a farmaci anti-tumorali

Responsabile

Prof. Alexis Grande (PO)

Personale strutturato, compreso quello tecnico

Dott. Tommaso Zanocco Marani (RU)

Assegnisti, Dottorandi, Borsisti, Contrattisti

Claudio Atene (assegnista)

 

Obiettivi dell'attività di ricerca

Caratterizzare il ruolo svolto da protocaderine e poteine tris-tetra-prolina nella carcinogenesi colo-rettale

 

Collaborazioni

Prof. Bruno Calabretta, Prof. Carlo Pincelli, Dott. Lorenzo Corsi (Unimore)

 

Fondi di ricerca

  • Fondazione di Vignola 2015 € 10.000
  • FAR Dipartimentale 2018 € 10.000
  • Fondazione Cassa di Risparmio di Modena 2014, € 250.000

 

Pubblicazioni più significative sull’argomento

  • Testa, F. Lotti, L. Cairns, A. Grande, S. Ottolenghi, G. Ferrari, A. Ronchi. Deletion of a negatively acting sequence in a chimeric GATA-1 enhancer – LTR greatly increases retroviral – mediated erythroid expression. Journal of Biological Chemistry 279: 10523-10531, 2004.
  • F. Urbinati, F. Lotti, G. Facchini, M. Montanari, G. Ferrari, F. Mavilio, A. Grande. Competitive engraftment of hematopoietic stem cells genetically modified with a truncated erythropoietin receptor. Human Gene Therapy 16: 594-608, 2005.
  • M. Montanari, C. Gemelli, E. Tenedini, T. Zanocco-Marani, T. Vignudelli, M. Siena, R. Zini, S. Salati, G. Chiossi, E. Tagliafico, R. Manfredini, A. Grande, S. Ferrari. Correlation between differentiation plasticity and mRNA expression profiling of CD34+ derived CD14- and CD14+ human normal myeloid precursors. Cell Death and Differentiation 12: 1588-1600, 2006.
  • C. Gemelli, M. Montanari, E. Tenedini, T. Zanocco Marani, T. Vignudelli, M. Siena, R. Zini, S. Salati, E. Tagliafico, R. Manfredini, A. Grande, Sergio Ferrari. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem / progenitor cells. Cell Death and Differentiation, 13:1686-1696, 2006.
  • E. Tagliafico, E. Tenedini, R. Manfredini, A. Grande, F. Ferrari, E. Roncaglia, S. Bicciato, R. Zini, S. Salati, E. Bianchi, C. Gemelli, M. Montanari, T. Vugnudelli, T. Zanocco-Marani, S. Parenti, P. Paolucci, G. Martinelli, P.P. Piccaluga, M. Bacarani, G. Specchia, U. Torelli, S. Ferrari. Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia. Leukemia, 20: 1751-1758, 2006.
  • C. Gemelli, C. Orlandi, T. Zanocco – Marani, A. Martello, T. Vignudelli, F. Ferrari, M. Montanari, S. Parenti, A. Testa, A. Grande, S. Ferrari. The Vitamin D3 / Hoax-A10 pathway supports MafB function during the monocyte differentiation of human CD34+ hemopoietic progenitors. Journal of Immunology, 181: 5660-5672, 2008.
  • A. Lymboussaki, C. Gemelli, A. Testa, G. Facchini, F. Ferrari, F. Mavilio, A. Grande. PPARdelta is a ligand dependent negative regulator of Vitamin D3 induced monocyte differentiation. Carcinogenesis, 30: 230 – 237, 2009.
  • T. Zanocco-Marani, T. Vignudelli, S. Parenti, C. Gemelli, F. Condorelli, A. Martello, T. Selmi, A. Grande, Sergio Ferrari. Tfe-3 transcription factor regulates the expression of MafB during macrophage differentiation. Experimental Cell Research 315: 1798 – 1808, 2009.
  • V. Salsi, S. Ferrari, R. Ferraresi, A. Cossarizza, A. Grande, V. Zappavigna. Hox-D13 binds DNA replication origins to promote origin licensing and is inhibited by Geminin. Molecular and Cellular Biology 29: 5775-5788, 2009.
  • S. Parenti, F. Ferrarini, R. Zini, M. Montanari, L. Losi, B. Canovi, S. Ferrari, A. Grande. Mesalazine inhibits the beta-catenin signaling pathway acting through the up-regulation of mu-protocadherin gene in colo-rectal cancer cells. Alimentary Pharmacology and Therapeutics, 31: 108-119, 2010.
  • T. Vignudelli , T. Selmi, A. Martello, S. Parenti, A. Grande, C. Gemelli, T. Zanocco-Marani, S. Ferrari. ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. Molecular Biology of the Cell, 21: 3340-51, 2010.
  • L. Losi, S. Parenti, F. Ferrarini, F. Rivasi, M. Gavioli, G. Natalini, S. Ferrari, A. Grande. Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis. Human Pathology, 42: 960-71, 2011.
  • T. Selmi, A. Martello, T. Vignudelli, E. Ferrari, A. Grande, C. Gemelli, P. Salomoni, S. Ferrari, T. ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways. Cell Cycle, 11: 1977-87, 2012.
  • C. Gemelli, A. Martello, M. Montanari, T. Zanocco Marani, V. Salsi, V. Zappavigna, S. Parenti, T. Vignudelli, T. Selmi, S. Ferrari, A. Grande. The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process. Experimental Cell Research, 319: 3201-13, 2013.
  • L. Losi, J. Benhattar, S. Pizzini, A. Bisognin, S. Parenti, L. Montorsi, C. Gemelli, T. Zanocco-Marani, P. Zanovello, F. Ferrarini, S. Ferrari, S. Bortoluzzi, A. Grande. Characterization of Clinical and Molecular Features Related to the Downregulated Expression of μ-Protocadherin in Colorectal Cancer. Journal of Carcinogenesis and Mutagenesis, 5: 1, 2014.
  • C. Gemelli, T. Zanocco Marani, S. Bicciato, E.M. Mazza, D. Boraschi, V. Salsi, V. Zappavigna, S. Parenti, T. Selmi, E. Tagliafico, S. Ferrari, A. Grande. MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation. Biochimica and Biophysica Acta, 1843: 955-64, 2014.
  • P. Italiani, E.M. Mazza, D. Lucchesi, I. Cifola, C. Gemelli, A. Grande, C. Battaglia, S. Bicciato, D. Boraschi. Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS One, 9: e87680, 2014.
  • L. Losi, A. Grande. Involvement of μ-protocadherin in colorectal carcinogenesis: a promise for clinico-pathological evaluation. Histology and Histopathology, 29: 11-19, 2014.
  • C. Gemelli, B.M. Dongmo, F. Ferrarini, A. Grande, L. Corsi. Cytotoxic effect of hemin in colonic epithelial cell line: involvement of 18 kDa translocator protein (TSPO). Life Sciences, 107: 14-20, 2014.
  • T. Selmi, C. Alecci, M. Dell' Aquila, L. Montorsi, A. Martello, F. Guizzetti, N. Volpi, S. Parenti, S. Ferrari, P. Salomoni, A. Grande, T. Zanocco-Marani. ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly. BMC Cancer, 15: 357, 2015.
  • G. Manzotti, S. Parenti, G. Ferrari-Amorotti, A.R. Soliera, S. Catellani, M. Montanari, D. Cavalli, A. Ertl, A. Grande, B. Calabretta. Monocyte-macrophage differentiation of HL60 cells by small molecules identified by interrogation of the Connectivity Map database. Cell Cycle, 14: 2578-2589, 2015.
  • S. Parenti, G. Casagrande, M. Montanari, M. Espahbodinia, R. Ettari, A. Grande, L. Corsi. A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line. Life Sciences, 152: 117-25, 2016
  • L. Montorsi, S. Parenti, L. Losi, F. Ferrarini, C. Gemelli, A. Rossi, G. Manco, S. Ferrari, B. Calabretta, E. Tagliafico, T. Zanocco-Marani, A. Grande. Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes. Cell Death and Disease, 7: e2263, 2016.
  • L. Montorsi, F. Guizzetti, C. Alecci, A. Caporali, A. Martello, C.G. Atene, S. Parenti, S. Pizzini, P. Zanovello, S. Bortoluzzi, S. Ferrari, A. Grande, T. Zanocco-Marani. Loss of ZFP36 expression in colorectal cancer correlates to Wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1. Oncotarget, 7: 59144-59157, 2016.
  • S. Parenti, L. Montorsi, S. Fantini, F. Mammoli, C. Gemelli, C. Atene, L. Losi, C. Frassineti, B. Calabretta, E. Tagliafico, S. Ferrari, T. Zanocco-Marani, A. Grande. KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells. Cancer Prevention Research, 11: 503-510, 2018.
  • L. Losi, C. Lancellotti, S. Parenti, T. Zanocco-Marani, F. Buffoli, R. Grassia, S. Ferrari, A. Grande. Loss of expression of μ-protocadherin and protocadherin-24 in sporadic and hereditary non polyposis colorectal cancers (HNPCC). Human Pathology, 84: 299-308, 2019.
  • F. Mammoli, S. Castiglioni, S. Parenti, C. Cappadone, G. Farruggia, S. Iotti, P. Davalli, J. Maier, A. Grande, C. Frassineti. Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃. International Journal Molecular Sciences, 20: e385, 2019.

[Ultimo aggiornamento: 18/06/2019 14:26:33]