Cardio-neurofarmacologia

  • Responsabile

    Prof. Daniela Giuliani (PA)

     

    Personale strutturato, compreso quello tecnico

    A. OTTANI, M. FILAFERRO, A. RUBERTO,

     

    Assegnisti, Dottorandi, Borsisti, Contrattisti

    E. VANDINI

     

    Obiettivi dell'attività di ricerca

    Studio di composti farmacologici in condizioni sperimentali di:

    - patologie neurodegenerative acute (ischemia cerebrale globale transitoria e ischemia cerebrale focale) e croniche (morbo di Alzheimer)

    - sofferenza ipossica (o da ischemia/riperfusione) in modelli animali in vivo quali shock emorragico, ischemia miocardica permanente e danno miocardico da ischemia/riperfusione,

     

    Collaborazioni

  • Prof. Jochem (Univ Zabrze, Polan)
  • Prof. Squadrito (Univ Messina)
  • Prof. Bocci (Univ. Pisa)
  • Prof. Bernini (Univ Parma)
  • Prof.ssa Rapposelli (Univ Pisa).
  •  

    Fondi di ricerca

  • FoRST 2014-2016
  • Fondazione Cassa di Risparmio di Modena 2015-2019
  • Terme di Salsomaggiore e Tabiano 2017-2020
  • FAR 2018-2020
  • Amgen 2018-2020
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    Pubblicazioni più significative sull’argomento

  • Giuliani D, Mioni C, Altavilla D, Leone S, Bazzani C, Minutoli L, Bitto A, Cainazzo MM, Marini H, Zaffe D, Botticelli AR, Pizzala R., Savio M, Necchi D, Schiöth HB, Bertolini A, Squadrito F, Guarini S. Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology  2006, 147:1126-1135  I.F.=4,503        Con editoriale: 
  • Altavilla D, Guarini S, Bitto A, Mioni C, Giuliani D, Bigiani A, Squadrito G, Minutoli L, Venuti FS, Messineo F, De Meo V, Bazzani C, Squadrito F. Activation of the cholinergic anti-inflammatory pathway reduces NF-kB activation, blunts TNF- production, and protects against splanchnic artery occlusion shock.  Shock  2006, 25:500-506  I.F.=3,045
  • Galeano M, Altavilla D, Bitto A,  Minutoli L,  Calò M, Lo Cascio P, Polito F, Giugliano G, Squadrito G, Mioni C, Giuliani D, Venuti FS, Squadrito F. Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds.Critical Care Medicine  2006, 34:1139-1146  I.F.=6,312    Con editoriale 
  • Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E., Colombo G, Tomasi A, Catania A, Guarini S. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. British  Journal of  Pharmacology  2007, 150:595-603  I.F.=4,842
  • Bitto A, Altavilla D, Polito F, Bonaiuto A, Minutoli L, Di Stefano V, Giuliani D, Guarini S, Arcoraci V, Squadrito F. Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome. Journal of Endocrinololgy  2009, 200:367-376    I.F.=3,718
  • Ottani A, Giuliani D, Mioni C, Galantucci M, Minutoli L, Bitto A, Altavilla D, Zaffe D, Botticelli AR, Squadrito F e Guarini S. 
  • Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke. Journal of  Cerebral Blood Flow & Metabolism  2009, 29:512-523    I.F.=5,407
  • Giuliani D, Ottani A, Minutoli L, Di Stefano V, Galantucci M, Bitto A, Zaffe D, Altavilla D, Botticelli AR., Squadrito F, Guarini S. Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268. Brain Behavior and  Immunity  2009, 23:804-850    I.F.=5,889
  • Bitto A, Polito F, Altavilla D, Irrera N, Giuliani D, Ottani A, Minutoli L, Spaccapelo L, Galantucci M, Lodi R, Guzzo G, Guarini S, Squadrito F. Melanocortins protect against multiple organ dysfunction syndrome in mice. British  Journal of  Pharmacology  2011,  162:917-928  I.F.= 4.842
  • Minutoli L, Squadrito F, Nicotina PA, Giuliani D, Ottani A, Polito F, Bitto A, Irrera N, Guzzo G, Spaccapelo L, Fazzari C, Macrì A, Marini H, Guarini S, Altavilla D. Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway. Critical Care Medicine  2011, 39:1089-1096  I.F.= 6,312  Con editoriale:  D
  • Giuliani D, Zaffe D, Ottani A, Spaccapelo L, Galantucci M, Minutoli L, Bitto A, Irrera N, Contri M, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery. Acta Neuropathologica 2011, 122:443-453  I.F.= 10,762
  • Bitto A, Polito F, Irrera N, Calò M, Spaccapelo L, Marini HR, Giuliani D, Ottani A, Rinaldi M, Minutoli L, Guarini S, Squadrito F, Altavilla D. Protective effects of melanocortins on short term changes in a rat model of traumatic brain injury. Critical Care Medicine  2012, 40:945-951  I.F.= 6,312   Con editoriale
  • Lonati C, Sordi A, Giuliani D, Spaccapelo L, Leonardi P, Carlin A, Ottani A, Galantucci M, Grieco P, Catania A, Guarini S. Molecular Changes Induced in Rat Liver by Hemorrhage and Effects of Melanocortin Treatment. Anesthesiology. 2012, 116:692-700     I.F.= 5,879
  • Giuliani D, Minutoli L, Ottani A, Spaccapelo L, Bitto A, Galantucci M, Altavilla D, Squadrito F, Guarini S. Melanocortins as potential therapeutic agents in severe hypoxic conditions. Frontiers In Neuroendocrinology 2012, 33:179-193    I.F.= 7,037
  • Ottani A, Galantucci M, Ardimento E, Neri L, Canalini F, Calevro A, Zaffe D,Novellino E, Grieco P, Giuliani D, Guarini S. Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion. Pharmacological Research 2013, 72:1-8      I.F.= 4,408
  • Giuliani D, Ottani A, Zaffe D, Galantucci M, Strinati F, Lodi R, Guarini S. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of Learning and Memory 2013, 104:82-91  I.F.= 3,652 
  • Giuliani D, Bitto A, Galantucci M,  Zaffe D, Ottani A,  Irrera N, Neri L, Cavallini G M, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Melanocortins protect against progression of Alzheimer’s disease in triple-transgenic mice by targeting multiple pathophysiological pathways.  Neurobiology Aging  2014, 35:537-547         I.F.= 5,013
  • Giuliani D, Neri L, Canalini F, Calevro A, Ottani A, Vandini E, Sena P, Zaffe D, Guarini S. NDP-α-MSH induces intense neurogenesis and cognitive recovery in Alzheimer transgenic mice through activation of melanocortin MC(4) receptors. Mol. Cell Neurosci. 2015, 67:13-21   I.F.=3,84
  •  Jochem J, Altinbas B, Yalcin M, Ottani A, Giuliani D, Savci V, Kasperska-Zajac  A, Guarini S. Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats. Journal of physiology and pharmacology  2016, 67:67-74.  I.F.= 2.72
  • Giuliani D, Ottani A, Neri L, Zaffe D, Grieco P, Jochem J, Cavallini GM, Catania A, Guarini S.  Multiple beneficial effects of melanocortin MC(4) receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives. Progress in Neurobiology  2017, 148:40-56    I.F= 13,177 
  • Pasqualetti F, Orlandi P, Simeon V, Cantarella M, Giuliani D, Di Desidero T, Gonnelli A, Delishaj D, Lombardi G, Sechi A, Sanson M, Zagonel V, Paiar F, Danesi R, Guarini S, Bocci G.  Melanocortin Receptor-4 Gene Polymorphisms in Glioblastoma Patients Treated with Concomitant Radio-Chemotherapy. Molecular  Neurobiology  2018,  55:1396-1404  doi: 10.1007/s12035-017-0414-9.         I.F.= 6.190 
  • Vaglini F, Pardini C, Di Desidero T, Orlandi P, Pasqualetti F, Ottani A, Giuliani D, Guarini S, Bocci G. Melanocortin receptor-4 and glioblastoma cells: effects of the selective antagonist ML00253764 alone and in combination with temozolomide on cell proliferation and apoptosis. Molecular  Neurobiology 2018  55:4984-4997. doi: 10.1007/s12035-017-0702-4      I.F.= 6.190
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[Ultimo aggiornamento: 14/02/2020 11:31:30]