Endocrinologia Clinica, Molecolare e Cellulare

  • Responsabile

    Prof.ssa Manuela Simoni (PO)

    Personale strutturato, compreso quello tecnico

    Prof. Vincenzo Rochira (PA)

    Dr. Livio Casarini (RTDb)

    Dr. Daniele Santi (RTDa)

    Dr. Claudia Anzivino (PTA)

    Assegnisti, Dottorandi, Borsisti, Contrattisti

    Dr. Giulia Brigante (PhD, MD, post-Doc fellow), Dr. Samantha Sperduti (PhD, post-Doc fellow), Dr. Maria Laura Monzani (MD, post-MD fellow), Clara Lazzaretti (PhD student), Elia Paradiso (PhD student), Andrea Craparo (MD resident), Maria Chiara De Caroli (MD resident), Sara De Vincentis (MD resident), Daniela Domenici (MD resident), Michela Locaso (MD resident), Gianluca Margiotta (MD resident), Simone Pederzoli (MD resident), Francesca Piccinini (MD resident), Antonio Russo (MD resident), Giulia Tartaro (MD resident), Gisella Boselli (MD resident), Gianluca Margiotta (MD resident)

     

    Obiettivi dell'attività di ricerca

    L’Unità di Endocrinologia svolge attività di ricerca che comprende sia studi clinici, che di base/traslazionali, nell’ambito dell’endocrinologia della riproduzione, dell’andrologia, della fisiopatologia tiroidea, del diabete, dell’arteriosclerosi, del deficit di GH dell’adulto e delle disfunzioni endocrine associate a trattamento dell’HIV. È di particolare rilevanza la linea di ricerca sulla risposta cellulare agli ormoni glicoproteici e steroidei, quali gonadotropine, tireotropina ed estrogeni, nonché lo studio degli aspetti farmacogenetici associati. Un’altra importante linea di ricerca riguarda il ruolo degli estrogeni nel maschio e l’osteoporosi maschile.

     

    Collaborazioni

    Local and national collaborations:

  • CORELAB Unit, AUSL Modena, Italy (Dr. Tommaso Trenti)
  • Dept. Life Sciences, University of Modena and Reggio Emilia, Modena, Italy (Prof. Francesca Fanelli; Dr. Giulia Di Rocco)
  • Dept. Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy (Prof. Antonio La Marca)
  • Dept. Histology, University of Tor Vergata, Rome, Italy (Dr. Francesca G. Klinger)
  • Dept. Neurosciences, University of Parma, Parma, Italy (Dr. Francesco Potì)
  • Dept. of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Rozzano, Italy (Prof. Andrea G. Lania)
  • Humanitas Fertility Center, Department of Gynaecology, Division of Gynaecology and Reproductive Medicine, Humanitas Research Hospital, Rozzano (Milan), Italy (Prof. Paolo Emanuele Levi-Setti)
  • Units of Obstetrics and Gynecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy (Dr. Maria Teresa Villani)
  • Dept.Surgical Sciences, S. Anna Hospital, University of Torino, Torino, Italy (Prof. Alberto Revelli)
  • Dept. Biology, University of Pisa, Pisa, Italy (Prof. Stefano Landi)
  • Dept. Clinical and Experimental Medicine, University of Pisa, Pisa, Italy (Prof. Rossella Elisei)
  • Department of Cultural and linguistic study, University of Modena and Reggio Emilia, Modena, Italy (Prof. Claudio Baraldi)
  • Sexual Medicine and Andrology Unit, Department of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy (Prof. Mario Maggi)
  • International collaborations:

  • Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (Prof. Kari Hemminki)
  • Institute of Human Genetics and Centre of Reproductive Medicine and Andrology, University of Münster, Germany (Prof. Frank Tüttelmann; Prof. Joerg Gromoll)
  • BIOS Group, PRC, INRA, CNRS, Université François Rabelais-Tours, Nouzilly, France (Prof. Eric Reiter)
  • Dept. Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates (Dott. Mohammed A. Ayoub)
  • Centre for Neuroendocrinology and Mammal Research Institute, University of Pretoria, Pretoria, South Africa (Prof. Robert P. Millar; Dr. Claire L. Newton)
  • Dept. Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK (Prof. Aylin C. Hanyaloglu)
  • Dept. of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland (Prof. Adolfo Rivero-Muller).
  • Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (Prof. Gerd Krause).
  • Dept. of Endocrinology & Department of Clinical and Experimental Medicine, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium (Prof. Dirk Vanderschueren)
  • Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (Prof. Robin Peeters)
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    Fondi di ricerca

  • PRIN 2017 from Italian Ministry of University and Research
  • PRIN 2015 from Italian Ministry of University and Research
  • Other funds were provided by Pharmaceutical Companies for clinical and in vitro studies
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    Pubblicazioni più significative sull’argomento

  • Brigante G, Riccetti L, Lazzaretti C, Rofrano L, Sperduti S, Potì F, Diazzi C, Prodam F, Guaraldi G, Lania AG, Rochira V, Casarini L. Abacavir, nevirapine, and ritonavir modulate intracellular calcium levels without affecting GHRH-mediated growth hormone secretion in somatotropic cells in vitro. Mol Cell Endocrinol. 2019;482:37-44.
  • De Vincentis S, Monzani ML, Brigante G. Crosstalk between gonadotropins and thyroid axis. Minerva Ginecol. 2018;70(5):609-620.
  • Casarini L, Riccetti L, Limoncella S, Lazzaretti C, Barbagallo F, Pacifico S, Guerrini R, Tagliavini S, Trenti T, Simoni M, Sola M, Di Rocco G. Probing the effect of sildenafil on Progesterone and Testosterone production by an intracellullar FRET/BRET combined approach. Biochemistry. 2018 Dec 11. doi: 10.1021/acs.biochem.8b01073.
  • Casarini L, Santi D, Brigante G, Simoni M. Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG. Endocr Rev. 2018;39(5):549-592.
  • Casarini L, Santi D, Simoni M, Potì F. 'Spare' Luteinizing Hormone Receptors: Facts and Fiction. Trends Endocrinol Metab. 2018;29(4):208-217.
  • Rochira V, Antonio L, Vanderschueren D. EAA clinical guideline on management of bone health in the andrological outpatient clinic. Andrology. 2018;6(2):272-285.
  • Santi D, Magnani E, Michelangeli M, Grassi R, Vecchi B, Pedroni G, Roli L, De Santis MC, Baraldi E, Setti M, Trenti T, Simoni M. Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years. Environ Pollut. 2018;235:806-813.
  • Santi D, Spaggiari G, Simoni M. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses. Reprod Biomed Online. 2018;37(3):315-326.

[Ultimo aggiornamento: 18/06/2019 13:19:52]